Derby Clinical Trials Support Unit

Royal Derby Hospital, Level 4 West Building, University of Nottingham GEM School

University Hospitals of Derby & Burton NHS Foundation Trust

Uttoxeter Road, Derby, DE22 3DT

This study is funded by the NIHR HTA (Ref: 133874). The views expressed are those of the author(s) and not necessarily those of the NIHR, the Department of Health and Social Care or the NHS.